- Title
- Decoding causal links between sleep apnea and alzheimer's disease
- Creator
- Ferini-Strambi, Luigi; Hensley, Michael; Salsone, Maria
- Relation
- Journal of Alzheimer's Disease Vol. 80, Issue 1, p. 29-40
- Publisher Link
- http://dx.doi.org/10.3233/JAD-201066
- Publisher
- IOS Press
- Resource Type
- journal article
- Date
- 2021
- Description
- Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are two common chronic diseases with a well-documented association. Whether the association is causal has been highlighted by recent evidence reporting a neurobiological link between these disorders. This narrative review discusses the brain regions and networks involved in OSA as potential vulnerable areas for the development of AD neuropathology with a particular focus on gender-related implications. Using a neuroimaging perspective supported by neuropathological investigations, we provide a new model of neurodegeneration common to OSA and AD, that we have called OSA-AD neurodegeneration in order to decode the causal links between these two chronic conditions.
- Subject
- alzheimer’s disease; amygdala; cingulate gyrus; hippocampus; insula; magnetic resonance imaging; obstructive sleep apnea
- Identifier
- http://hdl.handle.net/1959.13/1461883
- Identifier
- uon:46325
- Identifier
- ISSN:1387-2877
- Language
- eng
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